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XB-PHENO-27332

Xla Wt + Tg(Hsa.NKX2-1-GR) [FG], Hyatt BA et al. (2025)

Experiment + Assay: Xla Wt + Tg(Hsa.NKX2-1-GR) [FG] + NF39 (in situ hybridization)
Background: Xla.Inbred
Manipulations:
Manipulation Type Reagent Target Gene Stage Treatment Area
transgenesis Tg(Hsa.NKX2-1-GR) nkx2-1 (Xla)
 NF stage 4 (8-cell) dorsal animal hemisphere blastomere
chemical dexamethasone
NF stage 13
Conditions:
Assay Type Assay Stages Antibody
in situ hybridization NF stage 39  
Expression Phenotypes (6):
absent fabp2.L expression in midgut primordium
mislocalised sftpc.L expression in foregut endoderm
mislocalised sftpc.L expression in hindgut endoderm
increased amount sftpc.L expression in lung bud
mislocalised sox2.L expression in hindgut endoderm
mislocalised sox2.L expression in midgut
Source: Fig. 1C c4
Article: XB-ART-61398, PubMed