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XB-PHENO-27236

Xtr Wt + ndufa4 CRISPR, Marquez J et al. (2025)

Experiment + Assay: Xtr Wt + ndufa4 CRISPR + NF45 (RNA-Seq)
Background: Xtr.NigerianKhok
Manipulations:
Manipulation Type Reagent Target Gene Stage Treatment Area
CRISPR ndufa4 gRNA1 ndufa4
 NF stage 1 whole organism
Conditions:
Assay Type Assay Stages Antibody
RNA-Seq NF stage 45  
Anatomical Phenotypes: abnormal polyamine homeostasis
Expression Phenotypes (3):
decreased amount azin1 expression in whole organism
decreased amount oaz1 expression in whole organism
decreased amount odc1 expression in whole organism
Human Disease Associations: mitochondrial metabolism disease, Leigh disease
Source: Fig. 3 DE
Article: XB-ART-61222, PubMed