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XB-PHENO-24759

Xtr Wt + ift70a CRISPR, Getwan M et al. (2021)

Experiment + Assay: Xtr Wt + ift70a CRISPR + NF37/38-42 (immunohistochemistry)
Background: Xtr.Outbred
Manipulations:
Manipulation Type Reagent Target Gene Stage Treatment Area
CRISPR ift70a gRNA1 ift70a
 NF stage 2 (2-cell) blastomere
Conditions:
Assay Type Assay Stages Antibody
immunohistochemistry NF stage 37 and 38 to NF stage 42 Tuba4b Ab4
Anatomical Phenotypes: abnormally decreased number of cilium in the multiciliated cell, decreased size of the cilium in the multiciliated cell
Human Disease Associations: kidney disease, ciliopathy
Source: Fig. 5 C D
Article: XB-ART-58465, PubMed