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XB-PHENO-24286

Xtr Wt + nup188 MO, Del Viso F et al. (2016)

Experiment + Assay: Xtr Wt + nup188 MO + NF28-31 (in situ hybridization)
Background: Xtr.Outbred
Manipulations:
Manipulation Type Reagent Target Gene Stage Treatment Area
morpholino injection nup188 MO1 nup188
 NF stage 2 (2-cell) left blastomere
Conditions:
Assay Type Assay Stages Antibody
in situ hybridization NF stage 28 to NF stage 31  
Expression Phenotypes (2):
absent pitx2 expression in lateral plate mesoderm
mislocalised pitx2 expression in lateral plate mesoderm
Human Disease Associations: congenital heart disease, visceral heterotaxy
Source: Fig. 1 D E
Article: XB-ART-52470, PubMed