FIGUTRE 8. Genes repressing or being downregulated during cancer development/progression show varied expression patterns in Xenopus embryos. A, spatial expression patterns were examined with WMISH. Embryos at the same stages as shown in Fig. 6 were used and presented in the same way as in Fig. 6. A, anterior; ad, adenohypophysial placode; ba, branchial arch; cg, cement gland; cgp, cement gland primordium; ep, epidermis; ev, ear vesicle; ey, eye; fb, forebrain; hb, hindbrain; le, lens; mb, midbrain; mhb, midbrain-hindbrain boundary; nc, notochord; nu, neuron; np, neural plate; nt, neural tube; P, posterior; pn, pronephros; pm, paraxial mesoderm; ps, posterior somite; sm, somite; tg, trigeminal nerve. B, summary of the relatedness of gene expression/function in cancer and their expression.
Image published in: Zhang Z et al. (2017)
Copyright © 2017. Image reproduced with permission of the Publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License.
| Gene | Synonyms | Species | Stage(s) | Tissue |
|---|---|---|---|---|
| apc.S | xapc | X. laevis | Sometime during NF stage 15 to NF stage 20 | neuroectoderm neural plate |
| arid1a.S | LOC108707477, LOC108708921 | X. laevis | Sometime during NF stage 15 to NF stage 20 | neuroectoderm neural plate neural tube |
| axin1.S | axin, fused, xAxin | X. laevis | Sometime during NF stage 15 to NF stage 20 | |
| brms1.L | X. laevis | Sometime during NF stage 15 to NF stage 20 | ||
| casp9.S | caspase 9, caspase-9, caspase9, iCasp9, xCaspase-9 | X. laevis | Sometime during NF stage 15 to NF stage 20 | neuroectoderm neural plate |
| cdkn1a.L | cip1, p16Xic2, p21 | X. laevis | Sometime during NF stage 15 to NF stage 20 | cement gland primordium ectoderm |
| cdkn1b.S | cdkn4, kip1, LOC108710741, LOC492306, men1b, men4, p16Xic3, p17Xic3, p27kip1 | X. laevis | Sometime during NF stage 15 to NF stage 20 | neural plate |
| cdkn2b.L | cdk4l, ink4b, mts2, p15, p15ink4b, tp15 | X. laevis | Sometime during NF stage 15 to NF stage 20 | neural plate |
| chfr.L | X. laevis | Sometime during NF stage 15 to NF stage 20 | neural plate neuroectoderm | |
| dlc1.S | LOC108698560, LOC108706599, rhogap7 | X. laevis | Sometime during NF stage 15 to NF stage 20 | neuroectoderm neural plate |
| dmbt1.S | glycoprotein 340, gp-340, gp340, hensin, LOC108716130, muclin, salivary agglutinin | X. laevis | Sometime during NF stage 15 to NF stage 20 | ectoderm |
| gas1.L | X. laevis | Sometime during NF stage 15 to NF stage 20 | neuroectoderm neural plate paraxial mesoderm epidermis | |
| hexim1.L | X. laevis | Sometime during NF stage 15 to NF stage 20 | neuroectoderm neural plate | |
| hic1.L | X. laevis | Sometime during NF stage 15 to NF stage 20 | neuron neuroectoderm | |
| mgmt.L | LOC108697181 | X. laevis | Sometime during NF stage 15 to NF stage 20 | |
| pbrm1.L | LOC108705353, pb1 | X. laevis | Sometime during NF stage 15 to NF stage 20 | neuroectoderm neural plate |
| pdcd4.L | h731 | X. laevis | Sometime during NF stage 15 to NF stage 20 | neuroectoderm neural plate ectoderm |
| perp.S | kcp1, krtcap1, pigpc1, thw | X. laevis | Sometime during NF stage 15 to NF stage 20 | neuroectoderm |
| phlpp1.S | phlpp, plekhe1, scop | X. laevis | Sometime during NF stage 15 to NF stage 20 | |
| pten.L | X. laevis | Sometime during NF stage 15 to NF stage 20 | neuroectoderm neural plate ectoderm | |
| st13.S | X. laevis | Sometime during NF stage 15 to NF stage 20 | neuroectoderm neural plate | |
| tet2.L | X. laevis | Sometime during NF stage 15 to NF stage 20 | ||
| tgfbr1.S | aat5, acvrlk4, alk-5, alk5, lds1a, lds2a, LOC108719029, skr4, tgfr-1, TrR-1, xTrR-1 | X. laevis | Sometime during NF stage 15 to NF stage 20 | |
| tp53.L | p53, Trp248, tumor suppressor p53, Xp53, Xrel3 | X. laevis | Sometime during NF stage 15 to NF stage 20 | neuroectoderm neural plate |
| tp73.L | LOC108696624, LOC108697705, xP73 | X. laevis | Sometime during NF stage 15 to NF stage 20 | |
| tp53bp2.L | X. laevis | Sometime during NF stage 15 to NF stage 20 | neuroectoderm neural plate cement gland primordium | |
| txnip.L | X. laevis | Sometime during NF stage 15 to NF stage 20 | ||
| apc.S | xapc | X. laevis | Sometime during NF stage 26 to NF stage 32 | brain forebrain midbrain hindbrain central nervous system eye branchial arch trigeminal ganglion head pharyngeal region neurogenic placode |
| arid1a.S | LOC108707477, LOC108708921 | X. laevis | Sometime during NF stage 26 to NF stage 32 | brain forebrain midbrain hindbrain central nervous system eye branchial arch head pharyngeal region intermediate mesoderm |
| axin1.S | axin, fused, xAxin | X. laevis | Sometime during NF stage 26 to NF stage 32 | |
| brms1.L | X. laevis | Sometime during NF stage 26 to NF stage 32 | ||
| casp9.S | caspase 9, caspase-9, caspase9, iCasp9, xCaspase-9 | X. laevis | Sometime during NF stage 26 to NF stage 32 | brain forebrain midbrain hindbrain head eye pharyngeal region somite central nervous system |
| cdkn1a.L | cip1, p16Xic2, p21 | X. laevis | Sometime during NF stage 26 to NF stage 32 | cement gland somite eye otic vesicle lens placode |
| cdkn1b.S | cdkn4, kip1, LOC108710741, LOC492306, men1b, men4, p16Xic3, p17Xic3, p27kip1 | X. laevis | Sometime during NF stage 26 to NF stage 32 | |
| cdkn2b.L | cdk4l, ink4b, mts2, p15, p15ink4b, tp15 | X. laevis | Sometime during NF stage 26 to NF stage 32 | head pharyngeal region |
| chfr.L | X. laevis | Sometime during NF stage 26 to NF stage 32 | brain forebrain midbrain hindbrain central nervous system head pharyngeal region otic vesicle eye paraxial mesoderm | |
| dlc1.S | LOC108698560, LOC108706599, rhogap7 | X. laevis | Sometime during NF stage 26 to NF stage 32 | |
| dmbt1.S | glycoprotein 340, gp-340, gp340, hensin, LOC108716130, muclin, salivary agglutinin | X. laevis | Sometime during NF stage 26 to NF stage 32 | |
| gas1.L | X. laevis | Sometime during NF stage 26 to NF stage 32 | brain midbrain hindbrain central nervous system somite otic vesicle head | |
| hexim1.L | X. laevis | Sometime during NF stage 26 to NF stage 32 | pronephric nephrostome head eye pharyngeal region tail bud otic vesicle brain | |
| hic1.L | X. laevis | Sometime during NF stage 26 to NF stage 32 | trigeminal ganglion notochord | |
| mgmt.L | LOC108697181 | X. laevis | Sometime during NF stage 26 to NF stage 32 | |
| pbrm1.L | LOC108705353, pb1 | X. laevis | Sometime during NF stage 26 to NF stage 32 | central nervous system brain eye forebrain midbrain hindbrain pharyngeal region otic vesicle |
| pdcd4.L | h731 | X. laevis | Sometime during NF stage 26 to NF stage 32 | eye lens placode midbrain-hindbrain boundary |
| perp.S | kcp1, krtcap1, pigpc1, thw | X. laevis | Sometime during NF stage 26 to NF stage 32 | |
| phlpp1.S | phlpp, plekhe1, scop | X. laevis | Sometime during NF stage 26 to NF stage 32 | |
| pten.L | X. laevis | Sometime during NF stage 26 to NF stage 32 | head brain eye pharyngeal region central nervous system otic vesicle branchial arch forebrain midbrain hindbrain | |
| st13.S | X. laevis | Sometime during NF stage 26 to NF stage 32 | brain hindbrain central nervous system eye head pharyngeal region otic vesicle midbrain intermediate mesoderm | |
| tet2.L | X. laevis | Sometime during NF stage 26 to NF stage 32 | brain forebrain midbrain midbrain-hindbrain boundary central nervous system head eye pharyngeal region | |
| tgfbr1.S | aat5, acvrlk4, alk-5, alk5, lds1a, lds2a, LOC108719029, skr4, tgfr-1, TrR-1, xTrR-1 | X. laevis | Sometime during NF stage 26 to NF stage 32 | |
| tp53.L | p53, Trp248, tumor suppressor p53, Xp53, Xrel3 | X. laevis | Sometime during NF stage 26 to NF stage 32 | brain midbrain hindbrain midbrain-hindbrain boundary head eye pharyngeal region central nervous system otic vesicle branchial arch presomitic mesoderm |
| tp73.L | LOC108696624, LOC108697705, xP73 | X. laevis | Sometime during NF stage 26 to NF stage 32 | |
| tp53bp2.L | X. laevis | Sometime during NF stage 26 to NF stage 32 | brain forebrain midbrain midbrain-hindbrain boundary head eye pharyngeal region pronephric mesenchyme otic vesicle central nervous system | |
| txnip.L | X. laevis | Sometime during NF stage 26 to NF stage 32 | somite ventral mesoderm |
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