Figure 2. Expression profiles of Xenopus laevis Zic genes during embryonic development. Whole-mount in situ hybridization (WMISH) analyses with digoxigenin-labeled probes were performed to determine the spatial expression patterns of each Zic gene during development. Uppercase labels represent embryos stained with a Zic probe (A, Zic1; B, Zic2; C, Zic3; D, Zic4; E, Zic5). Lowercase labels indicate embryo stages (a, stage 11.5; b, 15; c, 19; d and e, 23; f, 26; g-i, 33). In b, arrows indicate the prospective region of hyoid crest and branchial crest, which have high Zic1 and Zic4 expression, and arrowheads show the anterior neural plate border region, with high levels of Zic5. e is the frontal view of the embryo shown in d. Arrowheads in d and e indicate the expression in eye (red), somite (green), lateral mesoderm (blue), and olfactory placode (white). h is a higher-magnification view of the embryo shown in g. i shows the transverse section of the WMISH sample of stage 33. The position of the section in i is indicated by a thin line in g. nt, neural tube; nc, notochord; ey, eye.
Image published in: Fujimi TJ et al. (2006)
Copyright © 2006. Image reproduced with permission of the Publisher, John Wiley & Sons.
| Gene | Synonyms | Species | Stage(s) | Tissue |
|---|---|---|---|---|
| zic4.L | X. laevis | Throughout NF stage 11.5 | anterior neural fold | |
| zic1.S | LOC100493456, odd-paired-like, opl, Zic-r1, Zic-related-1 | X. laevis | Throughout NF stage 11.5 | neural plate anterior neural fold |
| zic3.S | xzic3, Zinc finger protein of the cerebellum 3 | X. laevis | Throughout NF stage 11.5 | anterior neural fold neural plate |
| zic2.L | hpe5, xzic2, zic2-a, zic2-b, Zinc finger protein of the cerebellum 2 | X. laevis | Throughout NF stage 11.5 | anterior neural fold |
| zic5.S | X. laevis | Throughout NF stage 11.5 | anterior neural fold | |
| zic1.S | LOC100493456, odd-paired-like, opl, Zic-r1, Zic-related-1 | X. laevis | Throughout NF stage 15 | neural plate neural crest cranial neural crest hyoid crest branchial crest |
| zic2.L | hpe5, xzic2, zic2-a, zic2-b, Zinc finger protein of the cerebellum 2 | X. laevis | Throughout NF stage 15 | neural plate |
| zic3.S | xzic3, Zinc finger protein of the cerebellum 3 | X. laevis | Throughout NF stage 15 | neural plate midbrain-hindbrain boundary |
| zic4.L | X. laevis | Throughout NF stage 15 | neural plate | |
| zic5.S | X. laevis | Throughout NF stage 15 | neural plate neuroectoderm | |
| zic1.S | LOC100493456, odd-paired-like, opl, Zic-r1, Zic-related-1 | X. laevis | Sometime during NF stage 19 to NF stage 23 | central nervous system somite |
| zic2.L | hpe5, xzic2, zic2-a, zic2-b, Zinc finger protein of the cerebellum 2 | X. laevis | Sometime during NF stage 19 to NF stage 23 | central nervous system eye |
| zic3.S | xzic3, Zinc finger protein of the cerebellum 3 | X. laevis | Sometime during NF stage 19 to NF stage 23 | central nervous system lateral plate mesoderm |
| zic4.L | X. laevis | Sometime during NF stage 19 to NF stage 23 | central nervous system olfactory placode somite | |
| zic5.S | X. laevis | Sometime during NF stage 19 to NF stage 23 | central nervous system eye | |
| zic5.S | X. laevis | Throughout NF stage 23 | eye neural fold roof plate anterior neural ridge | |
| zic1.S | LOC100493456, odd-paired-like, opl, Zic-r1, Zic-related-1 | X. laevis | Throughout NF stage 26 | somite brain forebrain midbrain hindbrain |
| zic2.L | hpe5, xzic2, zic2-a, zic2-b, Zinc finger protein of the cerebellum 2 | X. laevis | Throughout NF stage 26 | eye roof plate neural tube anterior neural tube |
| zic4.L | X. laevis | Throughout NF stage 26 | roof plate anterior neural ridge | |
| zic5.S | X. laevis | Throughout NF stage 26 | eye roof plate anterior neural ridge neural fold | |
| zic1.S | LOC100493456, odd-paired-like, opl, Zic-r1, Zic-related-1 | X. laevis | Throughout NF stage 33 and 34 | somite forebrain midbrain hindbrain roof plate |
| zic2.L | hpe5, xzic2, zic2-a, zic2-b, Zinc finger protein of the cerebellum 2 | X. laevis | Throughout NF stage 33 and 34 | lens neural tube anterior neural tube roof plate |
| zic4.L | X. laevis | Throughout NF stage 33 and 34 | roof plate anterior neural ridge neural fold | |
| zic5.S | X. laevis | Throughout NF stage 33 and 34 | retina roof plate neural fold anterior neural ridge |
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