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Reciprocal inhibitory interneurones in the Xenopus embryospinal cord.
Dale N
.
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The mechanism of reciprocal inhibition between antagonistic motor centres during swimming in the paralysed Xenopus embryo has been investigated further. Paired intracellular recordings have been made from interneurones and motoneurones in an attempt to identify neurones which make direct inhibitory synapses onto motoneurones on the opposite side of the spinal cord. A physiological class of inhibitory interneurones is described which, when stimulated by intracellular current passage, evoke short-latency, probably monosynaptic, strychnine-sensitive inhibitory potentials in contralateral motoneurones. These inhibitory interneurones fire once per swimming cycle in phase with the ipsilateral motor root discharge. They therefore have a pattern of activity which would cause them to inhibit motoneurones of the antagonistic motor centre at an appropriate part of the swimming cycle. The intracellular injection of horseradish peroxidase (HRP) has allowed the morphology of these inhibitory interneurones to be characterized. They have unipolar cell bodies with a thick proximal process with short dendrites which crosses the spinal cord ventrally and then bifurcates with one axonal branch ascending into the hind brain and the other descending the spinal cord. These anatomical features are typical of the 'commissural interneurones' first described by Roberts & Clarke (1982). There are also some inhibitory interneurones which can inhibit motoneurones on the same side of the spinal cord. At least some of these interneurones may be commissural interneurones with ipsilateral axons and they may play a role in the generation of the swimming rhythm.
Buchanan,
Identification of interneurons with contralateral, caudal axons in the lamprey spinal cord: synaptic interactions and morphology.
1982, Pubmed
Buchanan,
Identification of interneurons with contralateral, caudal axons in the lamprey spinal cord: synaptic interactions and morphology.
1982,
Pubmed
Calabrese,
Neural control of heartbeat in the leech, Hirudo medicinalis.
1983,
Pubmed
Clarke,
Interneurones in the Xenopus embryo spinal cord: sensory excitation and activity during swimming.
1984,
Pubmed
,
Xenbase
Clarke,
Sensory physiology, anatomy and immunohistochemistry of Rohon-Beard neurones in embryos of Xenopus laevis.
1984,
Pubmed
,
Xenbase
Cohen,
Strychnine eliminates alternating motor output during fictive locomotion in the lamprey.
1984,
Pubmed
CURTIS,
The time courses of excitatory and inhibitory synaptic actions.
1959,
Pubmed
Dale,
Excitatory amino acid receptors in Xenopus embryo spinal cord and their role in the activation of swimming.
1984,
Pubmed
,
Xenbase
Dale,
Dual-component amino-acid-mediated synaptic potentials: excitatory drive for swimming in Xenopus embryos.
1985,
Pubmed
,
Xenbase
Feldman,
Activity of interneurons mediating reciprocal 1a inhibition during locomotion.
1975,
Pubmed
Friesen,
Generation of a locomotory rhythm by a neural network with reccurrent cyclic inhibition.
1977,
Pubmed
Jankowska,
Synaptic actions of single interneurones mediating reciprocal Ia inhibition of motoneurones.
1972,
Pubmed
Kahn,
Experiments on the central pattern generator for swimming in amphibian embryos.
1982,
Pubmed
,
Xenbase
Kling,
Simulation of rhythmic nervous activities. I. Function of networks with cyclic inhibitions.
1968,
Pubmed
Perkel,
Motor pattern production in reciprocally inhibitory neurons exhibiting postinhibitory rebound.
1974,
Pubmed
Roberts,
The neuroanatomy of an amphibian embryo spinal cord.
1982,
Pubmed
,
Xenbase
Selverston,
Cooperative mechanisms for the production of rhythmic movements.
1983,
Pubmed
Soffe,
Activity of myotomal motoneurons during fictive swimming in frog embryos.
1982,
Pubmed
,
Xenbase
Soffe,
Tonic and phasic synaptic input to spinal cord motoneurons during fictive locomotion in frog embryos.
1982,
Pubmed
,
Xenbase
Soffe,
Activity of commissural interneurons in spinal cord of Xenopus embryos.
1984,
Pubmed
,
Xenbase
SZEKELY,
LOGICAL NETWORK FOR CONTROLLING LIMB MOVEMENTS IN URODELA.
1965,
Pubmed
