Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Echinobase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
Echinobase
ECB-ART-53246
J Physiol 2024 Sep 15; doi: 10.1113/JP286449.
Show Gene links Show Anatomy links

Hypothyroidism alters the rhythmicity of the central clock, body temperature and metabolism: evidence of Bmal1 transcriptional regulation by T3.

Emrich F , Gomes BH , Selvatici-Tolentino L , Lopes RA , Secio-Silva A , Carvalho-Moreira JP , Bittencourt-Silva PG , Guarnieri LO , Silva ABP , Drummond LR , da Silva GSF , Szawka RE , Moraes MFD , Coimbra CC , Peliciari-Garcia RA , Bargi-Souza P .


???displayArticle.abstract???
and RQ and alterations in the neuronal activity pattern of MPOM. In GH3 cells, T3 increased Bmal1 promoter activity in a time-dependent manner. Thyroid hormone may act as a temporal cue for the central circadian clock, and the uncoupling of central and peripheral clocks might contribute to a wide range of metabolic and thermoregulatory impairments observed in hypothyroidism. KEY POINTS: Hypothyroidism alters clock gene expression in the suprachiasmatic nucleus (SCN). Thyroid hypofunction alters the phase of spontaneous locomotor activity and body temperature rhythms. Thyroid hormone deficiency alters the daily pattern of SCN and medial preoptic nucleus neuronal activities. Hypothyroidism alterations are extended to daily oscillations of oxygen consumption and metabolism, which might contribute to the development of metabolic syndrome. Triiodothyronine increases Bmal1 promoter activity acting as temporal cue for the central circadian clock.

???displayArticle.pubmedLink??? 39277824
???displayArticle.link??? J Physiol
???displayArticle.grants??? [+]