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Echinobase
ECB-ART-52366
Dev Growth Differ 1983 Jan 01;255:469-475. doi: 10.1111/j.1440-169X.1983.00469.x.
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Trifluoperazine-Sensitive Step during Sea Urchin, Echiuroid and Pelecypod Egg Activation: (trifluoperazine/calmodulin/calcium/maturation/fertilization).

Meijer L , Dube F , Guerrier P .


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Trifluoperazine, a calmodulin-antagonist, is shown to inhibit egg activation by ionophore A 23187 in sea urchin (I50 : 43 μM), by trypsin in echiufoids (I50 : 22 μM) and by KCl in bivalves (I50 : 34 μM). In each case the inhibition could be reversed by washing the eggs and the trifluoperazine-sensitive period was clearly limited. In Barnea and Urechis, trifluoperazine inhibits calcium uptake. A common trifluoperazine-sensitive step, possibly involving calmodulin, may thus be shared by a variety of animal groups during egg activation.

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