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Bioact Mater
2023 Jul 01;25:677-688. doi: 10.1016/j.bioactmat.2022.07.009.
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3D Printed Biomimetic Metamaterials with Graded Porosity and Tapering Topology for Improved Cell Seeding and Bone Regeneration.
Zhang L
,
Wang B
,
Song B
,
Yao Y
,
Choi SK
,
Yang C
,
Shi Y
.
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Biomimetic metallic biomaterials prepared for bone scaffolds have drawn more and more attention in recent years. However, the topological design of scaffolds is critical to cater to multi-physical requirements for efficient cell seeding and bone regeneration, yet remains a big scientific challenge owing to the coupling of mechanical and mass-transport properties in conventional scaffolds that lead to poor control towards favorable modulus and permeability combinations. Herein, inspired by the microstructure of natural sea urchin spines, biomimetic scaffolds constructed by pentamode metamaterials (PMs) with hierarchical structural tunability were additively manufactured via selective laser melting. The mechanical and mass-transport properties of scaffolds could be simultaneously tuned by the graded porosity (B/T ratio) and the tapering level (D/d ratio). Compared with traditional metallic biomaterials, our biomimetic PM scaffolds possess graded pore distribution, suitable strength, and significant improvements to cell seeding efficiency, permeability, and impact-tolerant capacity, and they also promote in vivo osteogenesis, indicating promising application for cell proliferation and bone regeneration using a structural innovation.
Amin Yavari,
Relationship between unit cell type and porosity and the fatigue behavior of selective laser melted meta-biomaterials.
2015, Pubmed
Amin Yavari,
Relationship between unit cell type and porosity and the fatigue behavior of selective laser melted meta-biomaterials.
2015,
Pubmed
Bobbert,
Additively manufactured metallic porous biomaterials based on minimal surfaces: A unique combination of topological, mechanical, and mass transport properties.
2017,
Pubmed
Chang,
Influence of pore size of porous titanium fabricated by vacuum diffusion bonding of titanium meshes on cell penetration and bone ingrowth.
2016,
Pubmed
Ciasca,
Recent advances in superhydrophobic surfaces and their relevance to biology and medicine.
2016,
Pubmed
Davoodi,
Additively Manufactured Gradient Porous Ti-6Al-4V Hip Replacement Implants Embedded with Cell-Laden Gelatin Methacryloyl Hydrogels.
2021,
Pubmed
Di Luca,
Gradients in pore size enhance the osteogenic differentiation of human mesenchymal stromal cells in three-dimensional scaffolds.
2016,
Pubmed
Do,
3D Printing of Scaffolds for Tissue Regeneration Applications.
2015,
Pubmed
Entezari,
Architectural Design of 3D Printed Scaffolds Controls the Volume and Functionality of Newly Formed Bone.
2019,
Pubmed
Erisken,
Functionally graded electrospun polycaprolactone and beta-tricalcium phosphate nanocomposites for tissue engineering applications.
2008,
Pubmed
Feng,
3D Printing of Lotus Root-Like Biomimetic Materials for Cell Delivery and Tissue Regeneration.
2017,
Pubmed
Feng,
Osteointegration of 3D-Printed Fully Porous Polyetheretherketone Scaffolds with Different Pore Sizes.
2020,
Pubmed
Gómez,
Design and properties of 3D scaffolds for bone tissue engineering.
2016,
Pubmed
Hwangbo,
Lotus-Root-Like Microchanneled Collagen Scaffold.
2021,
Pubmed
Karageorgiou,
Porosity of 3D biomaterial scaffolds and osteogenesis.
2005,
Pubmed
Langdahl,
Bone modeling and remodeling: potential as therapeutic targets for the treatment of osteoporosis.
2016,
Pubmed
Li,
Nanoscaled Bionic Periosteum Orchestrating the Osteogenic Microenvironment for Sequential Bone Regeneration.
2020,
Pubmed
Li,
Additively manufactured biodegradable porous iron.
2018,
Pubmed
Li,
Additively manufactured functionally graded biodegradable porous iron.
2019,
Pubmed
Liao,
Exosomes from mesenchymal stem cells modulate endoplasmic reticulum stress to protect against nucleus pulposus cell death and ameliorate intervertebral disc degeneration in vivo.
2019,
Pubmed
Nune,
Functional response of osteoblasts in functionally gradient titanium alloy mesh arrays processed by 3D additive manufacturing.
2017,
Pubmed
Park,
Trabecular bone organoid model for studying the regulation of localized bone remodeling.
2021,
Pubmed
Petrochenko,
Laser 3D printing with sub-microscale resolution of porous elastomeric scaffolds for supporting human bone stem cells.
2015,
Pubmed
Ramu,
Optimization of the configuration of porous bone scaffolds made of Polyamide/Hydroxyapatite composites using Selective Laser Sintering for tissue engineering applications.
2018,
Pubmed
Ritchie,
The conflicts between strength and toughness.
2011,
Pubmed
Scheinpflug,
Journey into Bone Models: A Review.
2018,
Pubmed
Shuai,
Accelerated degradation of HAP/PLLA bone scaffold by PGA blending facilitates bioactivity and osteoconductivity.
2021,
Pubmed
Syahrom,
Permeability studies of artificial and natural cancellous bone structures.
2013,
Pubmed
Tan,
Nature-Inspired Nacre-Like Composites Combining Human Tooth-Matching Elasticity and Hardness with Exceptional Damage Tolerance.
2019,
Pubmed
Tan,
Fabrication and characterization of three-dimensional poly(ether- ether- ketone)/-hydroxyapatite biocomposite scaffolds using laser sintering.
2005,
Pubmed
Tertuliano,
The nanocomposite nature of bone drives its strength and damage resistance.
2016,
Pubmed
Wang,
Evaluating 3D-printed biomaterials as scaffolds for vascularized bone tissue engineering.
2015,
Pubmed
Wang,
Lessons from the Ocean: Whale Baleen Fracture Resistance.
2019,
Pubmed
Weber,
Reconsidering Osteoconduction in the Era of Additive Manufacturing.
2019,
Pubmed
Wegst,
Bioinspired structural materials.
2015,
Pubmed
Yang,
Microstructure evolution and texture tailoring of reduced graphene oxide reinforced Zn scaffold.
2021,
Pubmed
Zhang,
3D printing of Haversian bone-mimicking scaffolds for multicellular delivery in bone regeneration.
2020,
Pubmed
Zhang,
Tailored mechanical response and mass transport characteristic of selective laser melted porous metallic biomaterials for bone scaffolds.
2020,
Pubmed
