Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Echinobase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
Echinobase
ECB-ART-34882
Biokhimiia 1983 Oct 01;4810:1747-51.
Show Gene links Show Anatomy links

[Inhibition of DNA biosynthesis in sea urchin embryos by 2'',3''-dideoxy-3''-aminonucleosides].

Kukhanova MK , Kochetkova SV , Kraevskiĭ AA , Terent'ev LL , Rasskazov VA .


???displayArticle.abstract???
It was shown that 3''-deoxy-3''-aminothymidine and 2'',3''-dideoxy-3''-aminoadenosine are effective inhibitors of DNA synthesis of sea urchin (Paracentrotus lividus) embryos during the early steps of development. The most probable mechanism of inhibition includes the blocking of the template-directed polycondensation, in which the inhibitors act as analogs of the substrates--thymidine and 2''-deoxyadenosine 5''-triphosphates. An efficient degradation of the newly synthesized DNA was observed during the inhibition.

???displayArticle.pubmedLink??? 6605765



Genes referenced: LOC100887844 LOC590297