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ECB-ART-34476
Nucleic Acids Res 1980 May 10;89:1893-912. doi: 10.1093/nar/8.9.1893.
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Codon frequencies in 119 individual genes confirm consistent choices of degenerate bases according to genome type.

Grantham R , Gautier C , Gouy M .


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The poor printing of our previous Figure 2 (1) is corrected. Codon usage in mRNA sequences just published is also given. A new correspondence analysis is done, based on simultaneous comparison in all mRNA of use of the 61 codons. This analysis reinforces our claim that most genes in a genome, or genome type, have the same coding strategy; that is, they show similar choices among synonymous codons, or among degenerate bases (2). Like analysis on frequency variation in the amino acids coded reveals an entirely different pattern.

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References [+] :
Alton, Nucleotide sequence analysis of the chloramphenicol resistance transposon Tn9. 1980, Pubmed