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Proc Natl Acad Sci U S A
1969 Nov 01;643:857-62. doi: 10.1073/pnas.64.3.857.
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Mitotic abnormalities in sea urchin embryos exposed to Dactinomycin.
Kiefer BI
,
Entelis CF
,
Infante AA
.
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Dactinomycin at concentrations of 10, 20, 25, and 50 mug/ml causes mitotic abnormalities in sea urchin embryos. Sister chromosome separation is impaired and anaphase bridges are frequently formed. The result is an unequal distribution of the chromosome complement to daughter cells. Possible explanations are discussed.
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