Click
here to close Hello! We notice that
you are using Internet Explorer, which is not supported by Echinobase
and may cause the site to display incorrectly. We suggest using a
current version of Chrome,
FireFox,
or Safari.
Pharmaceuticals (Basel)
2022 Nov 09;1511:. doi: 10.3390/ph15111374.
Show Gene links
Show Anatomy links
2-Butoxytetrahydrofuran and Palmitic Acid from Holothuria scabra Enhance C. elegans Lifespan and Healthspan via DAF-16/FOXO and SKN-1/NRF2 Signaling Pathways.
Jattujan P
,
Srisirirung S
,
Watcharaporn W
,
Chumphoochai K
,
Kraokaew P
,
Sanguanphun T
,
Prasertsuksri P
,
Thongdechsri S
,
Sobhon P
,
Meemon K
.
???displayArticle.abstract???
Extracts from a sea cucumber, Holothuria scabra, have been shown to exhibit various pharmacological properties including anti-oxidation, anti-aging, anti-cancer, and anti-neurodegeneration. Furthermore, certain purified compounds from H. scabra displayed neuroprotective effects against Parkinson's and Alzheimer's diseases. Therefore, in the present study, we further examined the anti-aging activity of purified H. scabra compounds in a Caenorhabditis elegans model. Five compounds were isolated from ethyl acetate and butanol fractions of the body wall of H. scabra and characterized as diterpene glycosides (holothuria A and B), palmitic acid, bis (2-ethylhexyl) phthalate (DEHP), and 2-butoxytetrahydrofuran (2-BTHF). Longevity assays revealed that 2-BTHF and palmitic acid could significantly extend lifespan of wild type C. elegans. Moreover, 2-BTHF and palmitic acid were able to enhance resistance to paraquat-induced oxidative stress and thermal stress. By testing the compounds' effects on longevity pathways, it was shown that 2-BTHF and palmitic acid could not extend lifespans of daf-16, age-1, sir-2.1, jnk-1, and skn-1 mutant worms, indicating that these compounds exerted their actions through these genes in extending the lifespan of C. elegans. These compounds induced DAF-16::GFP nuclear translocation and upregulated the expressions of daf-16, hsp-16.2, sod-3 mRNA and SOD-3::GFP. Moreover, they also elevated protein and mRNA expressions of GST-4, which is a downstream target of the SKN-1 transcription factor. Taken together, the study demonstrated the anti-aging activities of 2-BTHF and palmitic acid from H. scabra were mediated via DAF-16/FOXO insulin/IGF and SKN-1/NRF2 signaling pathways.
Amine,
Palmitic acid promotes resistin-induced insulin resistance and inflammation in SH-SY5Y human neuroblastoma.
2021, Pubmed
Amine,
Palmitic acid promotes resistin-induced insulin resistance and inflammation in SH-SY5Y human neuroblastoma.
2021,
Pubmed
Balcombe,
Ageing: definitions, mechanisms and the magnitude of the problem.
2001,
Pubmed
Berdichevsky,
A stress response pathway involving sirtuins, forkheads and 14-3-3 proteins.
2006,
Pubmed
Bordbar,
High-value components and bioactives from sea cucumbers for functional foods--a review.
2011,
Pubmed
,
Echinobase
Carta,
Palmitic Acid: Physiological Role, Metabolism and Nutritional Implications.
2017,
Pubmed
Chalorak,
Holothuria scabra extracts exhibit anti-Parkinson potential in C. elegans: A model for anti-Parkinson testing.
2018,
Pubmed
,
Echinobase
Chalorak,
Diterpene glycosides from Holothuria scabra exert the α-synuclein degradation and neuroprotection against α-synuclein-Mediated neurodegeneration in C. elegans model.
2021,
Pubmed
,
Echinobase
Chumphoochai,
Saponin-enriched extracts from body wall and Cuvierian tubule of Holothuria leucospilota reduce fat accumulation and suppress lipogenesis in Caenorhabditis elegans.
2019,
Pubmed
,
Echinobase
Detienne,
SKN-1-independent transcriptional activation of glutathione S-transferase 4 (GST-4) by EGF signaling.
2016,
Pubmed
Dong,
Bromophenol Bis (2,3,6-Tribromo-4,5-dihydroxybenzyl) Ether Protects HaCaT Skin Cells from Oxidative Damage via Nrf2-Mediated Pathways.
2021,
Pubmed
Driver,
The effect of dietary fat on longevity of Drosophila melanogaster.
1979,
Pubmed
Fisher,
The nuclear hormone receptor DAF-12 has opposing effects on Caenorhabditis elegans lifespan and regulates genes repressed in multiple long-lived worms.
2006,
Pubmed
Guha,
The longevity effect of cranberry extract in Caenorhabditis elegans is modulated by daf-16 and osr-1.
2013,
Pubmed
Haider,
Free radical scavengers: An overview on heterocyclic advances and medicinal prospects.
2020,
Pubmed
Hou,
Ageing as a risk factor for neurodegenerative disease.
2019,
Pubmed
Jattujan,
Holothuria scabra extracts possess anti-oxidant activity and promote stress resistance and lifespan extension in Caenorhabditis elegans.
2018,
Pubmed
,
Echinobase
Kitisin,
Saponin-rich extracts from Holothuria leucospilota mediate lifespan extension and stress resistance in Caenorhabditis elegans via daf-16.
2019,
Pubmed
,
Echinobase
Lee,
Elucidating the Mechanism of Weissella-dependent Lifespan Extension in Caenorhabditis elegans.
2015,
Pubmed
Li,
Palmitic acid up regulates Gal-3 and induces insulin resistance in macrophages by mediating the balance between KLF4 and NF-κB.
2021,
Pubmed
Liao,
Curcumin-mediated lifespan extension in Caenorhabditis elegans.
2011,
Pubmed
Lipina,
Modulation of cellular redox homeostasis by the endocannabinoid system.
2016,
Pubmed
López-Otín,
The hallmarks of aging.
2013,
Pubmed
Mancini,
Biological and Nutritional Properties of Palm Oil and Palmitic Acid: Effects on Health.
2015,
Pubmed
Milton,
Anandamide and noladin ether prevent neurotoxicity of the human amyloid-beta peptide.
2002,
Pubmed
Nishanthan,
Effects of processing on proximate and fatty acid compositions of six commercial sea cucumber species of Sri Lanka.
2018,
Pubmed
,
Echinobase
Oh,
JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16.
2005,
Pubmed
Okoro,
Bioactive Phytochemicals with Anti-Aging and Lifespan Extending Potentials in Caenorhabditis elegans.
2021,
Pubmed
Pangestuti,
Medicinal and health benefit effects of functional sea cucumbers.
2018,
Pubmed
,
Echinobase
Poljšak,
Free radicals and extrinsic skin aging.
2012,
Pubmed
Pranweerapaiboon,
An ethyl-acetate fraction of Holothuria scabra modulates inflammation in vitro through inhibiting the production of nitric oxide and pro-inflammatory cytokines via NF-κB and JNK pathways.
2020,
Pubmed
,
Echinobase
Pranweerapaiboon,
Methanolic Extract from Sea Cucumber, Holothuria scabra, Induces Apoptosis and Suppresses Metastasis of PC3 Prostate Cancer Cells Modulated by MAPK Signaling Pathway.
2021,
Pubmed
,
Echinobase
Raimondi,
Oncogenic pathways and the electron transport chain: a dangeROS liaison.
2020,
Pubmed
Rangsinth,
Leaf extract of Caesalpinia mimosoides enhances oxidative stress resistance and prolongs lifespan in Caenorhabditis elegans.
2019,
Pubmed
Schafer,
IFTA-2 is a conserved cilia protein involved in pathways regulating longevity and dauer formation in Caenorhabditis elegans.
2006,
Pubmed
Sun,
DAF-16/FOXO Transcription Factor in Aging and Longevity.
2017,
Pubmed
Tangrodchanapong,
Beneficial Effects of Cyclic Ether 2-Butoxytetrahydrofuran from Sea Cucumber Holothuria scabra against Aβ Aggregate Toxicity in Transgenic Caenorhabditis elegans and Potential Chemical Interaction.
2021,
Pubmed
,
Echinobase
Tissenbaum,
Using C. elegans for aging research.
2015,
Pubmed
Ueda,
Effect of dietary lipids on longevity and memory in the SAMP8 mice.
2011,
Pubmed
Uno,
Lifespan-regulating genes in C. elegans.
2016,
Pubmed
Wang,
Caenorhabditis elegans eyes absent ortholog EYA-1 is required for stress resistance.
2014,
Pubmed
Yurasakpong,
Holothuria scabra Extract Induces Cell Apoptosis and Suppresses Warburg Effect by Down-Regulating Akt/mTOR/HIF-1 Axis in MDA-MB-231 Breast Cancer Cells.
2021,
Pubmed
,
Echinobase
Zhang,
Caenorhabditis elegans as a Useful Model for Studying Aging Mutations.
2020,
Pubmed
Zhao,
Emodin extends lifespan of Caenorhabditis elegans through insulin/IGF-1 signaling pathway depending on DAF-16 and SIR-2.1.
2017,
Pubmed