Click
here to close Hello! We notice that
you are using Internet Explorer, which is not supported by Echinobase
and may cause the site to display incorrectly. We suggest using a
current version of Chrome,
FireFox,
or Safari.
Support Care Cancer
2019 Jul 01;277:2479-2486. doi: 10.1007/s00520-018-4519-0.
Show Gene links
Show Anatomy links
Chemotherapy-induced fatigue is associated with changes in gene expression in the peripheral blood mononuclear cell fraction of patients with locoregional breast cancer.
de Alcântara BBR
,
Cruz FM
,
Fonseca FLA
,
da Costa Aguiar Alves B
,
Perez MM
,
Varela P
,
Pesquero JB
,
de Iracema Gomes Cubero D
,
De Melo Sette CV
,
Del Giglio A
.
???displayArticle.abstract???
PURPOSE: Chemotherapy-induced fatigue (CIF) is a frequent symptom that impairs patient functioning and quality of life. We aimed to evaluate whether systemic chemotherapy can induce a specific gene expression profile in peripheral blood mononuclear cells (PBMNC) of patients with locoregional breast cancer (LRBC) who develop CIF.
METHODS: PBMNC were collected from 3 patients who developed CIF before and after their initial cycle of chemotherapy, and RNA-seq was performed in an Ion Torrent™ System. A total of 12.345 transcripts were sequenced, of which 26 were selected out of 71 that had significantly different expression before and after chemotherapy. The RNA-seq results were validated by RT-qPCR in a different group of 28 patients with LRBC who developed CIF after their first cycle of chemotherapy and in six patients who also received chemotherapy but did not develop CIF (controls). We assessed CIF according the BFI and Chalder Questionnaires.
RESULTS: We observed a significant increase in expression of DUSP18 and RHOBTB1 and decreased expression of NCAN and RAET1G in patients who developed CIF after chemotherapy. Control patients only exhibited a significant decrease in NCAN expression.
CONCLUSION: CIF induces specific changes in gene expression in the PBMNC of LRBC patients. Some of these changes, such as downregulation of NCAN expression, may reflect direct effects of chemotherapy since they are also observed in the controls. Furthermore, CIF may involve downregulation of skeletal muscle genes (RHOBT1, DUSP18) and immune systems (RAETG1), whereas NCAN downregulation may underlie the adverse cognitive effects of chemotherapy.
Aspenström,
Rho GTPases have diverse effects on the organization of the actin filament system.
2004, Pubmed
Aspenström,
Rho GTPases have diverse effects on the organization of the actin filament system.
2004,
Pubmed
Barreiro,
Protein carbonylation in skeletal muscles: impact on function.
2010,
Pubmed
Barsevick,
I'm so tired: biological and genetic mechanisms of cancer-related fatigue.
2010,
Pubmed
Bower,
Fatigue and gene expression in human leukocytes: increased NF-κB and decreased glucocorticoid signaling in breast cancer survivors with persistent fatigue.
2011,
Pubmed
Bower,
Cancer-related fatigue--mechanisms, risk factors, and treatments.
2014,
Pubmed
Brown,
The correlation between fatigue, physical function, the systemic inflammatory response, and psychological distress in patients with advanced lung cancer.
2005,
Pubmed
Campos,
Cancer-related fatigue: a practical review.
2011,
Pubmed
Cruz,
Biomarkers of fatigue related to adjuvant chemotherapy for breast cancer: evaluation of plasma and lymphocyte expression.
2015,
Pubmed
Einarsdottir,
Identification of NCAN as a candidate gene for developmental dyslexia.
2017,
Pubmed
Flowers,
Differential expression of genes and differentially perturbed pathways associated with very high evening fatigue in oncology patients receiving chemotherapy.
2018,
Pubmed
Gilliam,
Chemotherapy-induced weakness and fatigue in skeletal muscle: the role of oxidative stress.
2011,
Pubmed
Glatt,
Comparative gene expression analysis of blood and brain provides concurrent validation of SELENBP1 up-regulation in schizophrenia.
2005,
Pubmed
Halloran,
Prediction of the gene expression in normal lung tissue by the gene expression in blood.
2015,
Pubmed
Hsiao,
Genomic Profile of Fatigued Men Receiving Localized Radiation Therapy.
2016,
Pubmed
Iop,
Fatigue in cancer patients receiving chemotherapy: an analysis of published studies.
2004,
Pubmed
Jackson,
The Chalder Fatigue Scale (CFQ 11).
2015,
Pubmed
Kober,
Gene Expression Profiling of Evening Fatigue in Women Undergoing Chemotherapy for Breast Cancer.
2016,
Pubmed
Kramer,
Exercise, MAPK, and NF-kappaB signaling in skeletal muscle.
2007,
Pubmed
Landmark-Høyvik,
Alterations of gene expression in blood cells associated with chronic fatigue in breast cancer survivors.
2009,
Pubmed
Landmark-Høyvik,
The genetics and epigenetics of fatigue.
2010,
Pubmed
Lanier,
NKG2D Receptor and Its Ligands in Host Defense.
2015,
Pubmed
Larkin,
Fatigue in renal cell carcinoma: the hidden burden of current targeted therapies.
2010,
Pubmed
Mendoza,
The rapid assessment of fatigue severity in cancer patients: use of the Brief Fatigue Inventory.
1999,
Pubmed
Mishra,
Inflammatory cytokine-mediated evasion of virus-induced tumors from NK cell control.
2013,
Pubmed
Patterson,
Dual-specificity phosphatases: critical regulators with diverse cellular targets.
2009,
Pubmed
Saligan,
Upregulation of α-synuclein during localized radiation therapy signals the association of cancer-related fatigue with the activation of inflammatory and neuroprotective pathways.
2013,
Pubmed
Saligan,
The biology of cancer-related fatigue: a review of the literature.
2015,
Pubmed
Schultz,
Common variation in NCAN, a risk factor for bipolar disorder and schizophrenia, influences local cortical folding in schizophrenia.
2014,
Pubmed
Sullivan,
Evaluating the comparability of gene expression in blood and brain.
2006,
Pubmed
Wang,
Chemobrain: a critical review and causal hypothesis of link between cytokines and epigenetic reprogramming associated with chemotherapy.
2015,
Pubmed
Wang,
The NCAN gene: schizophrenia susceptibility and cognitive dysfunction.
2016,
Pubmed
Wang,
A systematic review of the association between fatigue and genetic polymorphisms.
2017,
Pubmed
Wang,
Pathophysiology of cancer-related fatigue.
2008,
Pubmed
Widegren,
Mitogen-activated protein kinase signal transduction in skeletal muscle: effects of exercise and muscle contraction.
2001,
Pubmed
Wright,
Long-term gross motor performance following treatment for acute lymphoblastic leukemia.
1998,
Pubmed
