Papers associated with LOC588766 (and LOC100887844)

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	PI3K inhibitors block skeletogenesis but not patterning in sea urchin embryos., Bradham CA, Miranda EL, McClay DR., Dev Dyn. April 1, 2004; 229 (4): 713-21.
	Sulfated polysaccharide isolated from the sea cucumber Stichopus japonicus promotes neurosphere migration and differentiation via up-regulation of N-cadherin., Sheng X, Li M, Song S, Zhang N, Wang Y, Liang H, Wang W, Ji A., Cell Mol Neurobiol. April 1, 2012; 32 (3): 435-42.
	Fucosylated chondroitin sulfate from sea cucumber in combination with rosiglitazone improved glucose metabolism in the liver of the insulin-resistant mice., Hu S, Chang Y, Wang J, Xue C, Li Z, Wang Y., Biosci Biotechnol Biochem. January 1, 2013; 77 (11): 2263-8.
	Eicosapentaenoic acid-enriched phosphatidylcholine isolated from Cucumaria frondosa exhibits anti-hyperglycemic effects via activating phosphoinositide 3-kinase/protein kinase B signal pathway., Hu S, Xu L, Shi D, Wang J, Wang Y, Lou Q, Xue C., J Biosci Bioeng. April 1, 2014; 117 (4): 457-63.
	Fucosylated chondroitin sulfate from sea cucumber improves glucose metabolism and activates insulin signaling in the liver of insulin-resistant mice., Hu SW, Tian YY, Chang YG, Li ZJ, Xue CH, Wang YM., J Med Food. July 1, 2014; 17 (7): 749-57.
	Fucosylated chondroitin sulfate from sea cucumber improves insulin sensitivity via activation of PI3K/PKB pathway., Hu S, Chang Y, He M, Wang J, Wang Y, Xue C., J Food Sci. July 1, 2014; 79 (7): H1424-9.
	Fucoidan from sea cucumber Cucumaria frondosa exhibits anti-hyperglycemic effects in insulin resistant mice via activating the PI3K/PKB pathway and GLUT4., Wang Y, Wang J, Zhao Y, Hu S, Shi D, Xue C., J Biosci Bioeng. January 1, 2016; 121 (1): 36-42.
	Fucoidan from sea cucumber may improve hepatic inflammatory response and insulin resistance in mice., Wang J, Hu S, Jiang W, Song W, Cai L, Wang J., Int Immunopharmacol. February 1, 2016; 31 15-23.
	Neuroprotective effect of sulfated polysaccharide isolated from sea cucumber Stichopus japonicus on 6-OHDA-induced death in SH-SY5Y through inhibition of MAPK and NF-κB and activation of PI3K/Akt signaling pathways., Cui C, Cui N, Wang P, Song S, Liang H, Ji A., Biochem Biophys Res Commun. February 5, 2016; 470 (2): 375-383.
	Sulfated polysaccharide isolated from the sea cucumber Stichopus japonicas promotes the SDF-1α/CXCR4 axis-induced NSC migration via the PI3K/Akt/FOXO3a, ERK/MAPK, and NF-κB signaling pathways., Cui C, Wang P, Cui N, Song S, Liang H, Ji A., Neurosci Lett. March 11, 2016; 616 57-64.
	Stichopus japonicus Polysaccharide, Fucoidan, or Heparin Enhanced the SDF-1α/CXCR4 Axis and Promoted NSC Migration via Activation of the PI3K/Akt/FOXO3a Signaling Pathway., Cui C, Wang P, Cui N, Song S, Liang H, Ji A., Cell Mol Neurobiol. November 1, 2016; 36 (8): 1311-1329.
	Vesicular PtdIns(3,4,5)P3 and Rab7 are key effectors of sea urchin zygote nuclear membrane fusion., Lete MG, Byrne RD, Alonso A, Poccia D, Larijani B., J Cell Sci. January 15, 2017; 130 (2): 444-452.
	Thyroid Hormones Accelerate Initiation of Skeletogenesis via MAPK (ERK1/2) in Larval Sea Urchins (Strongylocentrotus purpuratus)., Taylor E, Heyland A., Front Endocrinol (Lausanne). January 1, 2018; 9 439.
	Comparative toxicity evaluation of targeted anticancer therapeutics in embryonic zebrafish and sea urchin models., Babic T, Dinic J, Buric SS, Hadzic S, Pesic M, Radojkovic D, Rankov AD., Acta Biol Hung. December 1, 2018; 69 (4): 395-410.
	Cerebrosides from Sea Cucumber Improved Aβ1-42 -Induced Cognitive Deficiency in a Rat Model of Alzheimer''s Disease., Li Q, Che HX, Wang CC, Zhang LY, Ding L, Xue CH, Zhang TT, Wang YM., Mol Nutr Food Res. March 1, 2019; 63 (5): e1800707.
	Benzimidazolyl-pyrazolo[3,4-b]pyridinones, Selective Inhibitors of MOLT-4 Leukemia Cell Growth and Sea Urchin Embryo Spiculogenesis: Target Quest., Lichitsky BV, Komogortsev AN, Dudinov AA, Krayushkin MM, Khodot EN, Samet AV, Silyanova EA, Konyushkin LD, Karpov AS, Gorses D, Radimerski T, Semenova MN, Kiselyov AS, Semenov VV., ACS Comb Sci. December 9, 2019; 21 (12): 805-816.
	PI3K inhibition highlights new molecular interactions involved in the skeletogenesis of Paracentrotus lividus embryos., Chiaramonte M, Russo R, Costa C, Bonaventura R, Zito F., Biochim Biophys Acta Mol Cell Res. January 1, 2020; 1867 (1): 118558.
	A sea cucumber (Holothuria leucospilota) polysaccharide improves the gut microbiome to alleviate the symptoms of type 2 diabetes mellitus in Goto-Kakizaki rats., Zhao F, Liu Q, Cao J, Xu Y, Pei Z, Fan H, Yuan Y, Shen X, Li C., Food Chem Toxicol. January 1, 2020; 135 110886.

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